Abstract
In the present study, we investigated the effect of Lipo-PGE1 on peripheral diabetic neuropathy in genetically diabetic mice (C57BL/Ksj-db/db). To estimate the nerve function in diabetic and non-diabetic mice (C57BL/Ksj), the F-wave latency in the tibial nerve was measured as an index. The F-wave latencies in C57BL/Ksj and C57BL/Ksj-db/db were 4.73±0.20 msec and 5.81±0.17 msec, respectively, and a significant difference was observed (P<0.01). With daily intravenous administrations of Lipo-PGE1 (1 and 3μg) for 4 weeks, the prolonged F-wave latency in C57BL/Ksj-db/db was conspicuously improved, in a dose-dependent manner. The difference in F-wave latency between C57BL/Ksj and C57BL/Ksj-db/db increased from 0.4 msec to 1msec. These results suggest that Lipo-PGE1 is effective for diabetic peripheral neuropathy, and that F-wave measurement is useful as an index of peripheral neuropathy.
