Abstract
Male Dahl salt sensitive (S) and salt resistant (R) rats aged 8 weeks were randomly divided into two groups and respectively fed high-sucrose diet (HS) and high-fiber diet (HF) until 16 weeks of age. Moreover, a Dahl S rat group which was fed the HS containing 0.2% troglitazone, which potentiates insulin action and reduces insulin resistance, was designed. The body weights and plasma insulin levels in HS-fed groups significantly increased compared with those in HF-fed groups in both Dahl S and R rats. In Dahl S rats fed the HS diet, the plasma insulin levels and systolic blood pressure (BP) were significantly higher than those in Dahl S rats fed the HF diet. In contrast, hyperinsulinemia did not influence systolic BP in Dahl R rats. The troglitazone treatment in Dahl S rats abolished hyperinsulinemia and hyperinsulinemia-induced elevations in systolic BP.
In conclusion, hyperinsulinemia may contribute to elevations of systolic BP oniy in the salt-sensitive madel.
