Abstract
We investigated whether small dense low-density lipoprotein (LDL), an atherogenic lipoprotein, and lipid components may affect atherosclerotic vascular disease in pattjents with NIDDM. Subjects were 26 healthy controls and 118 patients with NIDDM. NIDDM patients were subdivided into four groups. 23, without atherosclerotic vascular disease, 59, with coronary heart disease (CHD), 16, with cerebrovascular disease (CVD), and 20, with arteriosclerosis obliterans in the lower limbs (ASO). After overnight fasting, LDL particle diameter was measured using the method by Krauss, pattern B (small dense LDL) was defined as a LDL particle diameter of less than25.5nm. Diabetic patients possessed lipoproteins richer in triglyceride and smaller in LDL particle diameter compared to the control. Pattern B was associated with CHD (odds ratio 2.96, 95% confidence interval 1.13 to7.74, p<0.05) and ASO (odds ratio 3.51, 95% confidence interval 1.03 to 11.9, p<0.05) in NIDDM patients. Multivariate linear regression analysis revealed that LDL particle diameter was determined by very low-density lipoprotein-triglyceride (VLDL-TG) and glycosylated hemoglobin (HbA1c). In conclusion, LDL particles were small in NIDDM patients regardless of the presence or absence and the type of atherosclerotic diseases.
