Abstract
A 55-year-old man was diagnosed with diabetes mellitus three years after the onset of SBMA. He had a family history of SBMA in a grandfather. Androgen receptor gene analysis revealed an increase in number of CAG repeats to 47. In spite of appropriate diet and exercise, periodic changes in HbA1c along with serum CK (MM type) and serum GPT occurred for 2 years. Close correlations were observed among the changes in serum CK, GPT, and HbA1c values during the clinical course. The HbA1c levels were positively correlated with the serum CK (r=0.535, p=0.0103), serum GPT levels (r= 0.475, p= 0.0294), and serum aldolase levels (r= 0.795, p= 0.0326). SBMA is an adult-onset neuron disease often accompanied by diabetes mellitus. However, the relationship between SBMA and diabetes mellitus has not been fully elucidated. Our findings suggest that muscular damage affected contorol of the diabetes mellitus in the patient.
