Abstract
Six transplantable rat prostate carcinoma lines were established from primary tumors developing in the dorsolateral prostate and a metastatic lesion in the liver of F344 rats receiving a combined treatment with 3,2'-dimethyl-4-aminobiphenyl (DMAB) and testosterone propionate (TP). Growth in the subcutis of nude mice (ICR-nu/nu) is rapid with a doubling time of approximately 10 days and transplantability is 100%. The histological appearance of the transplanted tumors (well- to moderately differentiated and poorly differentiated adenocarcinomas) is very similar to that of the primaries and their structures have not been altered by after 8 passages. Lung metastasis has been observed at frequencies of 30 to 100%. Androgen receptor immunohistochemistry revealed all to be negative. These data indicate that the lines should prove useful for studies of invasion, metastasis, and hormone dependency of prostate carcinomas.
