Mongolian Gerbils are not Susceptible to Induction of Intestinal Metaplasia in Gastric Mucosa by X-Irradiation

Huimei Lu; Katsuhisa Shiraki; Yoshimasa Ishimura; Masayuki Ohara; Toshihiro Uesaka; Osamu Katoh; Hiromitsu Watanabe

doi:10.1293/tox.15.45

Originals

Mongolian Gerbils are not Susceptible to Induction of Intestinal Metaplasia in Gastric Mucosa by X-Irradiation

Huimei Lu, Katsuhisa Shiraki, Yoshimasa Ishimura, Masayuki Ohara, Toshihiro Uesaka, Osamu Katoh, Hiromitsu Watanabe

Author information

Huimei Lu
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University
Katsuhisa Shiraki
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University
Yoshimasa Ishimura
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University
Masayuki Ohara
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University
Toshihiro Uesaka
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University
Osamu Katoh
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University
Hiromitsu Watanabe
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University

Keywords: Mongolian gerbils, X-irradiation, histopathological examination, gastric lesion, intestinal metaplasia

JOURNAL FREE ACCESS

2002 Volume 15 Issue 1 Pages 45

DOI https://doi.org/10.1293/tox.15.45

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Abstract

This study was designed to determine whether intestinal metaplasia can be induced in Mongolian gerbils (MGS) by X-irradiation. Five-week-old animals of both sexes were X-irradiated with two X-ray doses of 10 Gy each at a 3-day interval (total dose: 20 Gy) and killed 24 or 60 weeks thereafter for histopathological examination. Intestinal metaplasia was not detectable in either 11 male or 10 female MGS at 24 weeks and only two lesions were encountered at 60 weeks after X-irradiation. One was type A in a female and the other of type B in a male. These results demonstrated that the glandular stomach of Mongolian gerbils is not susceptible to induction of intestinal metaplasia by X-irradiation.

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