Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Technical Report
A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats
Motoki HojoYoshimitsu SakamotoAi MaenoKuniaki TayamaYukie TadaKatsuhiro YuzawaHiroshi AndoYoshikazu KuboAkemichi NagasawaKazuyoshi TanakaNorio YanoFujifumi KaihokoYuko HasegawaToshinari SuzukiAkiko InomataTakako MoriyasuKatsuhiro MiyajimaDai Nakae
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2020 Volume 33 Issue 1 Pages 47-55


Histopathological information about spontaneous lesions in aged Hannover Wistar rats is limited. In this study, we describe spontaneous lesions found in 39 male RccHan:WIST rats used as a control in a carcinogenicity study. Neoplastic lesions were frequently seen in the endocrine system, such as pituitary adenomas in the pars distalis. This strain exhibited a high incidence of thymoma (10.3%), compared to other strains. We encountered an oligodendroglioma, a pituitary adenoma of the pars intermedia, and a prostate adenocarcinoma, which are comparatively rare in rats. While the variety and incidence of non-neoplastic lesions were similar to those in other strains, several interesting lesions occurred with relatively high incidence, including “harderianization” of the extraorbital lacrimal gland, common bile duct ectasia, and hyperplasia of pulmonary endocrine cells in the lung. Furthermore, comparative analyses demonstrated that the severity of chronic progressive nephropathy and murine progressive cardiomyopathy in RccHan:WIST rats was less than that in F344 rats.

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© 2020 The Japanese Society of Toxicologic Pathology
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