Abstract
Potential modifying effects of dietary high fat on 3, 2'-dimethyl-4-aminobiphenyl (DMAB)-induced rat prostate and colon carcinogenesis were investigated in male F344 rats using a two stage, initiation-promotion protocol. Starting at 3 weeks of age, animals were given s.c. injections of DMAB (150mg/kg body weight/week for 3 consecutive weeks). Starting fifteen weeks after the last injection of DMAB, rats were fed semipurified diet containing 20% corn oil (high fat) or 4.5% corn oil (normal fat) for 42 weeks and then all animals were sacrificed for histopathological investigation. No significant effects of the high fat diet on the resultant incidences of atypical hyperplasia and carcinoma of the prostate or of tumor development in the colon were observed.
