Abstract
Chronological changes in hemodynamics and histopathological lesions of the brain were investigated in rats given a single dose of hypertonic glucose solution (osmotic ratio: 6.5) intravenously or intraperitoneally. After administration, dehydration developed rapidly and markedly but recovery was noted on the following day. An excess dosage of the hypertonic solution caused cerebral lesions with meningeal hemorrhage showing nervous signs. Shrinkage of neurons, and loosening and vacuolation of the ground substance with swollen astrocytes (spongy appearance) were seen mainly in CA4 subfield of the hippocampus. The spongy appearance occurred in cases which died 130 min or later post-administration (PA), while the ischaemic change consisting of necrosis and loss of neurons with glial proliferation was seen mainly in CA1 and CA4 of cases sacrificed 14 days PA. The cerebral lesions showed selective vulnerability and were considered to result from ischaemia caused by hemodynamic changes.
