Abstract
Early morphological changes in the kidney of Wistar rats given 5% diethylene glycol (DEG) in drinking water for 2, 4 or 6 days were studied. The kidney was fixed by perfusion with Karnovsky's solution and examined by a light microscopy and electron microscopy. The histological change appeared mainly in proximal convoluted tubules in cortex. At day 2, eosinophilic granules in the cytoplasm of proximal convoluted tubular epithelium increased in number and also lysosomal-like dense bodies increased in number. At day 4, focal necrosis with vacuoles usually appeared in the inner cortex, mitochondrias in proximal convoluted tubular epithelium were small or irregular sizes and high electron dense. At day 6, most of the cytoplasm of proximal convoluted tubular epithelium were occupied by various sizes of cystic vacuoles, and a few organelle located near cellar membrane on one side.
