Abstract
Five-week-old JCR: CD rats were administered either with 10% sodium chloride (NaCI) or with 10% ethanol in drinking water after a single dose of 20 Gy of X-irradiation exposed to the gastric region. One year after X-irradiation, the animals were sacrificed. The incidence of gastric tumors was 19% in the X-ray group, 37% in the X-ray plus NaCI, and 10% in the X-ray plus ethanol (X-ray+NaCl vs. X-ray+ethanol p<0.05). The frequency of intestinal metaplasia with alkaline phosphatase (ALP) positive foci in X-ray+NaCl was significantly decreased compared to those of the X-ray or X-ray+ethanol group. The heights of pyloric and fundic mucosa were increased in NaCI groups. It was concluded that 10% NaCI worked as a promotive for the gastric tumorigeneis induced by X-ray but was inhibitory for the appearance of intestinal metaplasia.
