Levels of PCB congeners in maternal blood and their effect on maternal and neonatal thyroid hormones - result from Hokkaido study on environment and children’s health

Toshiaki BABA; Eiji YOSHIOKA; Seiko SASAKI; Chihiro MIYASHITA; Motoyuki YUASA; Sachiko ITO; Jumboku KAJIWARA; Takashi TODAKA; Shizue KATO; Sumitaka KOBAYASHI; Emiko OKADA; Ikuko KASHINO; Thamar Ayo YILA; Titilola BRAIMOH; Reiko KISHI

doi:10.14869/toxpt.39.2.0.AP-107.0

The 6th International Congress of Asian Society of Toxicology

Session ID : AP-107

DOI https://doi.org/10.14869/toxpt.39.2.0.AP-107.0

Conference information

Host: The Japanese Society of Toxicology

Environmental chemical & Endocrine disruptor

Levels of PCB congeners in maternal blood and their effect on maternal and neonatal thyroid hormones - result from Hokkaido study on environment and children’s health

*Toshiaki BABA, Eiji YOSHIOKA, Seiko SASAKI, Chihiro MIYASHITA, Motoyuki YUASA, Sachiko ITO, Jumboku KAJIWARA, Takashi TODAKA, Shizue KATO, Sumitaka KOBAYASHI, Emiko OKADA, Ikuko KASHINO, Thamar Ayo YILA, Titilola BRAIMOH, Reiko KISHI

Author information

*Toshiaki BABA
Department of Public Health Sciences, Graduate School of Medicine, Hokkaido University, Japan
Eiji YOSHIOKA
Division of Community Medicine and Epidemiology, Asahikawa Medical College, Japan
Seiko SASAKI
Department of Public Health Sciences, Graduate School of Medicine, Hokkaido University, Japan
Chihiro MIYASHITA
Center for Environment and Health Sciences, Hokkaido University, Japan
Motoyuki YUASA
Department of Public Health, School of Medicine, Juntendo University, Japan
Sachiko ITO
Center for Environment and Health Sciences, Hokkaido University, Japan
Jumboku KAJIWARA
Fukuoka Institute of Health and Environmental Sciences, Japan
Takashi TODAKA
Fukuoka Institute of Health and Environmental Sciences, Japan
Shizue KATO
Department of Public Health Sciences, Graduate School of Medicine, Hokkaido University, Japan
Sumitaka KOBAYASHI
Department of Public Health Sciences, Graduate School of Medicine, Hokkaido University, Japan
Emiko OKADA
Department of Public Health Sciences, Graduate School of Medicine, Hokkaido University, Japan
Ikuko KASHINO
Department of Public Health Sciences, Graduate School of Medicine, Hokkaido University, Japan
Thamar Ayo YILA
Center for Environment and Health Sciences, Hokkaido University, Japan
Titilola BRAIMOH
Department of Public Health Sciences, Graduate School of Medicine, Hokkaido University, Japan
Reiko KISHI
Center for Environment and Health Sciences, Hokkaido University, Japan

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

Background: Reported evidence regarding relationships between PCBs at low exposure levels and thyroid homeostasis in adults and neonates has been considered contradictory.
Objectives: To investigate the relationship between maternal specific PCB congener levels and maternal and neonatal thyroid hormone (TH) levels.
Methods: We conducted a prospective cohort study of pregnant women from 2002 to 2005 in Sapporo, Japan. Maternal blood samples for measurement of PCBs were collected between 23 weeks of gestation and one week after delivery. Congener-specific analysis of PCBs was conducted using HRGC/HRMS. Maternal (n = 386) and infant (n = 411) blood samples for measurement of THs were obtained between 7 and 20 gestational weeks and between 4 and 7 days of age after birth, respectively. THs were measured by enzyme-linked immunosorbent assay as public screening program. Characteristics of mothers and their neonates were obtained from self-administered questionnaires and medical records.
Results: Maternal fT4 increased significantly with high non-ortho PCB concentrations. There were no significant associations among PCB levels and maternal TSH or neonatal TSH or fT4. Stratified analysis by neonatal gender showed no associations.

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