Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to a combination of imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice. IMZ/TBZ were given in the diet to provide levels of 0%/0% (control), 0.0015%/0.018% (IMZ/TBZ), 0.006%/0.018%, and 0.024%/0.018% during the gestation and lactation periods. Selected reproductive and neurobehavioral parameters were measured in the F1 generation. In behavioral development during the lactation period of the F1 generation, cliff avoidance on PND 7 in male offspring was restrained in a dose-related manner. In the exploratory behavior of the F1-generation offspring, the average time of rearing of males was lengthened in the high-dose group. In the exploratory behavior of the F1-generation adult females, the number of rearing decreased in the high-dose group, the average rearing time increased in a dose-related manner, and the number of defecations increased in the high-dose group. In the spontaneous behavior of F1 generation, the average speed of males was restrained in the high-dose group, and the parallel lines of the control and treatment groups indicated a significant distance in the average time of rearing in the F1-generation females. The low-dose level of IMZ was based on NOAEL of IMZ, and the fixed-dose level of TBZ was based on three-fold of NOAEL of TBZ. However, estimated IMZ/TBZ intakes from diets are lower than 1/400 and 1/2000 of ADI (0.03/0.1mg/kg/day). It seems unlikely that dietary intake levels of IMZ and TBZ produce neurobehavioral effects in humans.
