Placental transfer of ¹²⁵iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey

Abstract

In this study, we demonstrated placental transfer of hIgG2 in a nonhuman primate model, and at levels comparable to the rat model. Hence, rats also represent a biologically and clinically relevant species for placental transfer of hIgG2. Antibody was measured in the nonhuman primate and rat embryo/fetus during specific developmental windows, including organogenesis. Thus, direct antibody binding to biological targets present in the developing conceptus is conceivable, raising the potential for adverse developmental outcomes.