Intrauterine hypo-perfusion model for reproductive and developmental toxicology

Abstract

Various environmental pollutants possessing the developmental and reproductive toxicity cause fetal growth restriction (FGR) associated with intrauterine hypo-perfusion. To understand pathology of FGR, we established a novel intrauterine hypo-perfusion model, of which blood flow in uterus are gradually and continuously suppressed, in the present study. The novel animal model displayed a low birth weight and dysfunction of central nervous system that are typical manifestations in FGR. The study will contribute to promotion the reproductive and developmental toxicology research.