塩化アルミニウムの発達期曝露によるラット海馬歯状回神経新生への影響

菊地 聡美; 岡野 拡; 高橋 康徳; 高嶋 和巳; 山下 理紗子; 小林 美央; 吉田 敏則; 渋谷 淳

doi:10.14869/toxpt.47.1.0_P-183

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-183

DOI https://doi.org/10.14869/toxpt.47.1.0_P-183

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

Developmental exposure effect of aluminum chloride on hippocampal neurogenesis in rats

*Satomi KIKUCHI, Hiromu OKANO, Yasunori TAKAHASHI, Kazumi TAKASHIMA, Risako YAMASHITA, Mio KOBAYASHI, Toshinori YOSHIDA, Makoto SHIBUTANI

Author information

*Satomi KIKUCHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Hiromu OKANO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Yasunori TAKAHASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Kazumi TAKASHIMA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Risako YAMASHITA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Mio KOBAYASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Toshinori YOSHIDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Makoto SHIBUTANI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

This study examined developmental exposure effect of aluminum chloride (AlCl₃) on hippocampal neurogenesis in rats. Pregnant rats were administered 0, 0.25, or 0.5% AlCl₃ via drinking water from gestational day 6 to postnatal day (PND) 21, and offspring were examined on PND 21 and PND 77. As a result, AlCl₃ was considered to facilitate proliferation of type-2 to type-3 progenitor cells or inhibit differentiation to granule cell at the high dose on PND 21. Effect was recovered on PND 77. We compared the results of this study in rats with the previous study in mouse.

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