酢酸鉛の発達期曝露によるラット海馬神経新生に対する影響

山下 理紗子; 高橋 康徳; 菊地 聡美; 岡野 拡; 高嶋 和巳; 小林 美央; 吉田 敏則; 渋谷 淳

doi:10.14869/toxpt.47.1.0_P-184

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-184

DOI https://doi.org/10.14869/toxpt.47.1.0_P-184

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

Developmental exposure effect of lead acetate on hippocampal neurogenesis in rats

*Risako YAMASHITA, Yasunori TAKAHASHI, Satomi KIKUCHI, Hiromu OKANO, Kazumi TAKASHIMA, Mio KOBAYASHI, Toshinori YOSHIDA, Makoto SHIBUTANI

Author information

*Risako YAMASHITA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Yasunori TAKAHASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Satomi KIKUCHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Hiromu OKANO
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Kazumi TAKASHIMA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Mio KOBAYASHI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Toshinori YOSHIDA
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
Makoto SHIBUTANI
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology

CONFERENCE PROCEEDINGS FREE ACCESS

Details

Abstract

This study examined developmental exposure effect of lead acetate (PbAc) on hippocampal neurogenesis in rats. Maternal rats were administered 0, 2,000, or 4,000 ppm PbAc via drinking water from gestational day 6 to postnatal day (PND) 21, and offspring were examined on PND 21 and PND 77. As a result, PbAc facilitated proliferation of intermediate progenitor cells and inhibited differentiation to granule cell at high dose on PND 21, suggesting relation with enhanced CALB2+ interneuron signal and suppressed RELN signal, respectively. Effect on GABAergic interneurons sustained at the adult stage.

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