2つの繁殖施設で生産されたrasH2マウスの発がん感受性比較試験

井上 亮; 保田 昌彦; 西中 栄子; 西銘 千代子; 芳賀 秀幸; 望月 美沙; 川井 健司; 浦野 浩司

doi:10.14869/toxpt.47.1.0_P-190

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-190

DOI https://doi.org/10.14869/toxpt.47.1.0_P-190

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

Carcinogenic susceptibility comparative study on rasH2 mice produced by two breeding facilities

*Ryo INOUE, Masahiko YASUDA, Eiko NISHINAKA, Chiyoko NISHIME, Hideyuki HAGA, Misa MOCHIZUKI, Kenji KAWAI, Koji URANO

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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

The rasH2 mouse are produced by two breeding facilities, CLEA Japan, Inc. and Taconic Bioscience. In this study, we investigated the carcinogenic susceptibility of rasH2 mice derived from the two colonies replaced in 2016-2017. A total of 120 rasH2 mice obtained from the two facilities were divided into vehicle and MNU groups. We observed them for maximum 26 weeks, then investigated histopathologically. In MNU group, the incidence of forestomach papilloma/carcinoma was 93.9-100%. Therefore, Carcinogenic conformity of rasH2 mice produced by two facilities was confirmed in the present study.

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