ヒト臍帯組織のテロメア長と母体血および臍帯血 polychlorinated biphenyl（PCB）濃度の関連

髙橋 朋子; 田邉 裕美; 江口 哲史; 渡邉 応宏; 櫻井 健一; 森 千里

doi:10.14869/toxpt.47.1.0_P-217

The 47th Annual Meeting of the Japanese Society of Toxicology

Session ID : P-217

DOI https://doi.org/10.14869/toxpt.47.1.0_P-217

Conference information

Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster

Association between telomere length in human umbilical cord tissue and serum polychlorinated biphenyl (PCB) concentration

*Tomoko TAKAHASHI, Hiromi TANABE, Akifumi EGUCHI, Masahiro WATANABE, Kenichi SAKURAI, Chisato MORI

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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

We investigate the association between telomere length (TL) and fetal PCB exposure.

The subjects were 94 mother-child pairs participating in a birth cohort, the Chiba study of Mother and Child Health. Maternal and cord blood (CB) were collected during pregnancy and at birth, respectively. Cord tissue was obtained at birth. TL was assessed by qPCR using genomic DNA extracted from cord tissue. The maternal and cord serum levels of PCB congeners were assessed using GC-MS in cord serum were detected. Serum levels in CB of PCB99 for all or females showed a positive association with TL.

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