Transportable human neuron plates

Abstract

Neuron plates, neuronal networks cultured on microelectrode arrays, are widely used for toxicological assays. Human iPSC-derived neurons are extensively tested for this purpose to evaluate species-specific effects. In-house preparation of human neuron plates is costly, while using outside parties for neuron plate testing of proprietary compounds could have information security risks. To overcome these problems, we have developed transportable human neuron plates by optimizing culture conditions. We believe this technology can contribute to reduce the cost and risk of neurotoxicity testing.