Effects of microsampling on toxicokinetic parameters in comparison to conventional method, and investigation of alternate blood sampling route of microsampling on the anemic conditions in rats

Abstract

We compared the toxicokinetic parameters from tail vein microsampling (0.05 mL) and from conventional jugular vein sampling (0.2 mL) in rats. Six drugs of different types in modalities, administration route or distribution were administered. Furthermore, we evaluated the tail vein microsampling method under the anemic conditions in case of failure to collect sufficient amount of blood (0.05 mL) in toxicity studies. In that case, conventional jugular vein sampling (0.2 mL) was also applied and evaluated. The results will be reported in the poster presentation.