Silver nanoparticles upregulate amyloid precursor protein in SH-SY5Y cells

Abstract

We used human SH-SY5Y cells to investigate the effects of silver nanoparticles widely used in well-known products on amyloid-beta expression, a key molecule in Alzheimer’s disease. The present study showed that silver nanoparticles of 10 nm in diameter induced the protein level of amyloid precursor protein upregulation through oxidative stress and after amyloid-beta increment in SH-SY5Y cells. Our results provide basic evidence that the adverse effects of silver nanoparticles on the central nervous system.