Hazard identification and exploring of cross reactivity triggered by amorphous silica nanoparticles via acquired immunity

Abstract

We evaluated the effects of multiple dose of nSP50 (amorphous silica nanoparticles of 50 nm in diameter) on acute toxicities, when mice were pretreated and challenged with PBS or nSP50 to identify their inverse biological effects mediated by acquired immunity. As a result, the plasma level of hepatic damage markers in nSP50-pretreated mice was significantly increased compared to those in PBS-pretreated mice. On the other hand, it wasn’t observed in immunodeficiency mice. These results suggest nSP50-inducible hepatic damages would worsen by pre-treatment of nSP50 via acquired immune system.