Annual Meeting of the Japanese Society of Toxicology
The 47th Annual Meeting of the Japanese Society of Toxicology
Session ID : P-24S
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Host: The Japanese Society of Toxicology

Name : The 47th Annual Meeting of the Japanese Society of Toxicology

Date : 2020 -

Poster
The effect of silver nanoparticles on forskolin-induced BeWo syncytialization
*Yuji SAKAHASHI, Kazuma HIGASHISAKA, Ryo ISAKA, Nanan ISHIDA, Kotoe KIYOMOTO, Shintaro YAMAGUCHI, Go KITAHARA, Hirofumi TSUJINO, Kazuya NAGANO, Yasuo TSUTSUMI
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Abstract

We evaluated the effect of silver nanoparticles in 10 nm diameter (nAg10) on forskolin-induced BeWo syncytia. RT-PCR analysis found that the forskolin-induced up-regulation of Syncytin-1/2, syncytium-promoting molecules, were suppressed. Moreover, co-treatment of nAg10 with forskolin significantly reduced the forskolin-induced increase in nucleus size. These results suggest that nAg10 might inhibit the formation of the syncytium cells.

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