Exploring for new biomarkers using liver organoids derived from nonalcoholic steatohepatitis (NASH) model mice

Abstract

In recent years, the number of patients with nonalcoholic steatohepatitis (NASH) has been increasing. A new research tool to reproduce the NASH pathology has been demanded. We therefore generated organoids derived from liver tissue of NASH model mice. To generate liver organoids, we used different stages of NASH model mice (NASH A, NASH B, NASH C). As a result, we demonstrated that liver organoids derived from NASH model mice can reproduce the fibrotic pathology of NASH disease. It was also suggested that the gene whose expression increased could become a new biomarker of NASH.