Toxicological effects in adult male rats of two-hit exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) at neonatal and adult stages

Abstract

There is increasing concern about transient exposure in disaster and emergency. However, conventional toxicology testing methods may not address this situation. Thus, we assessed the toxic effects of a history of transient exposure in childhood stages by exposing male rats to tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) at their neonatal and adult stages. Rats receiving TDCIPP on both stages had significantly increased adrenal gland weight compared with rats receiving TDCIPP at adult stage only.