A modeling of restricted exposome for chemicals with protein-modifying capability

Abstract

There are a huge number of chemical substances in the environment. Among them, electrophiles are covalently bound to protein nucleophiles, resulting in formation of protein adducts involved in activation/disruption of cellular redox signaling pathways and toxicity. It should be noted that we are exposed to a variety of xenobiotic electrophiles on a daily basis through living environment, lifestyle and dietary habits. In the panel discussion, I introduce our findings to establish a modeling of xenobiotic electrophile exposome.