Epigenetic regulation via protein modification by environmental electrophiles

Abstract

Part of exogenous environmental chemicals such as electrophiles influences the enzymatic activity of proteins via covalent modification. Whereas, there has not been fully elucidated the effects of these chemicals on cells, tissues, organs, and body throughout life. Exposome is defined as the measure of all exposures of an individual in a lifetime and how those exposures relate to health and disease. Thus, it is very difficult for us to solve this huge issue (exposome) completely at present. We therefore decided to search how adduct formation by chemicals affect the intracellular functions and epigenetics. Emerging results revealed that exposure to some environmental chemicals affects epigenetics. In this symposium, I would present our recent results and discuss how we should deal with exposome.