New developments on lysine acyl modification research -Possibility of lysine adduct exposome by food constituent carboxylic acids-

Abstract

Lysine residue in proteins contains a highly reactive amino group that is targeted for various posttranslational modifications including acylation. Acyl modification on lysine residues is induced by endogenous carboxylic acids such as fatty acids through chemical reactions in vivo. We are exposed daily to various compounds including carboxylic acids with foods. These exogenous carboxylic acids may be also added to lysine residues of proteins in the body. In this presentation, we would like to introduce our research on lysine acyl modifications and discuss possible influences of exposure to food constituent carboxylic acids from the perspective of lysine adduct exposome.