Chemical-induced histopathological changes of rat placenta

Abstract

The placenta is an important organ for the development of fetuses. The placental dysfunction and injury have adverse effects on the maintenance of pregnancy and fetal development. However, the placental weight change is only one of the indexes of placental toxicity in developmental toxicity studies. Detecting chemical-induced histopathological placental damages in rats provides a valuable clue to the mechanisms of fetal toxicity in safety evaluation. In this presentation, I will introduce the histopathological placental changes in the rats exposed to cisplatin, ketoconazole, tamoxifen, etc.