Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
We aim to identify factors affecting species differences in fetal drug transfer. Species differences between human and rat in fetus-to-mother concentration ratio of digoxin and indomethacin were cancelled by using the unbound concentration ratio in rat. This can be explained from the fact that the lower albumin concentration in fetal plasma compared with maternal plasma is observed in rat but not in human. Organic anion transporter 4 found only in primates and mediates the transport of olmesartan, which may cause adverse pregnancy outcomes especially occurred in humans. These information enhance possibilities of improving the extrapolation of fetal drug transfer data from rodents to human.
