Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And because retinal diseases are most common among the elderly, developing pathological analyses and treatments for retinal diseases has become an urgent issue in super-aging countries such as Japan. Although evaluation of drug candidates against retinal diseases has been done on animal models, serious concerns arise regarding the ethics and costs in addition to the limitations of translating data from animal models to clinical settings. In vitro cell culture models, an alternative to animal models, enable researchers to investigate specific molecules-of-interest and simply recapitulate complex and chronic conditions. Here, an organ-on-a-chip that mimics retinal diseases using microfluidic devices will be presented.
