Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
The key technologies for realizing diagnosis of systemic diseases using saliva samples are biomarkers and biosensors. Chemical salivary test (salivary test) has overwhelming advantages over blood test in that it is intrinsically safe and test samples can be self-collected any time. However, a diagnostic methodology for systemic diseases cannot be established on the basis of these advantages alone. It is considered that the practical application of salivary test depends on the successful demonstration that either the diagnostic accuracy of the test is significantly higher than that of conventional techniques, or it can provide additional new information to aid medical treatments. To be specific, this involves the use of new biomarkers. Although rapid, low-cost and high sensitivity analytical techniques using saliva sampling have improved tremendously in recent years, the suggested applications of such techniques are still limited to viral infections and human stress tests. However, in the near future, salivary sensors will be practically applied to various systemic diseases as point-of-care testing (POCT). As a topic, cancer-related activation of cytokine networks are central aspects of tumor development. One of the goal of my study is to examine the possibility of salivary cytokines for the screening of cancer. This review focuses on the current status and future prospects of diagnostic methodologies using saliva samples for detection of diseases. The detection of new applications for salivary sensors is discussed.
