Development of novel SPE spin column using monolithic silica for analysis of drugs from biological sample

Abstract

Pretreatment of biological samples with very low concentration and small volume is an important procedures for LC-MS analysis. Solid phase extraction (SPE) is widely used for pretreatment of cannabis in biological samples. However, SPE methods involve time consuming steps, unsuitable for small sample volume and expensive preparatory equipment. Therefore, recent investigations have focused on pretreatment of cannabis to adapt for small sample volume, rapid treatment time, and the low cost. In this study, we reports a novel SEP spin column for extraction of drugs from biological samples.