Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
Microphysiological system (MPS) might be a promising tool for analysis of drug metabolism and toxicity in humans although limited information is available in quantitative approach for such purpose. We have introduced pressure-driven, medium circulation system for the entero-hepatic two-organ MPS recently developed in AIST (Tsukuba, Japan) into quantitative analysis of phase I- and II metabolism of several model drugs. Metabolic clearance of cytochrome P450 substrates and glucuronidation of hydroxyl metabolites in the two-organ MPS was higher than that observed in the single culture system, suggesting a certain gut-liver interaction involved in efficient drug metabolism. Plasma concentration profile of the model drug and its metabolites in humans was quantitatively simulated based on pharmacokinetic model in the MPS by incorporating several scaling factors. Thus, MPS would be effective tool for deep understanding of drug metabolism observed in multiple organs.
Arakawa H et al. Lab on a Chip 20, 537, 2020.
