Epigenome changes in the offspring affected by the fetal and neonatal environment and their remnants

Abstract

Epigenetic modifications are expected to change in fetuses and neonates and affect gene expression in the baby for long time. We collected biological samples of cases with pregnancy complications and preterm infants and found epigenomic changes in cord blood and placentas of these cases. Some changes are assumed to show "remaining immature epigenetic marks". In this symposium, we will give an overview of epigenome changes due to the environment observed in humans, including our original reports.