Host: The Japanese Society of Toxicology
Name : The 47th Annual Meeting of the Japanese Society of Toxicology
Date : 2020 -
Determination of the potential for developmental neurotoxicity (DNT) is necessary for assessing and evaluating the toxic characteristics of a chemical substance. Our aim is to study an electrophysiological developmental index at the lactation period to predict adverse effects after the development. Using hippocampal slices obtained from rat pups at lactation period, we found a sudden enhancement of stimulation/response relationship in the CA1 area on the day of eye-opening. Then, we investigated prenatally exposed to valproic acid (VPA) or tributyltin (TBT), known as a developmental neurotoxicant, and found that VPA accelerated but TBT decelerated the congenital development of hippocampal excitability programmed on the day of eye-opening. Thus, our experimental model can be verified to be useful for DNT evaluation.
