Application for drug discovery using mammalian artificial chromosomes

Abstract

We used chromosome engineering technology to develop human artificial chromosomes (HAC) and mouse artificial chromosomes (MAC) that can introduce large human genes, multiple human genes in a stable manner. In this presentation, we will introduce new drug discovery tools (fully human antibody-producing animal, human drug metabolism model animal, metabolic enzyme expressing cell, toxicity monitor cell, etc.) developed by HAC/MAC technology, and further introduce new combined technologies of DNA synthesis and HAC/MAC.