Case studies of target-mediated toxicity in antibody drug discovery

Abstract

In the non-clinical safety evaluation of antibody drugs, the specific binding mode of action is important for assessing target-based toxicity. Although monkeys are generally used for the non-clinical in vivo evaluation of antibody drugs, in vitro cell-based evaluation and understanding of Fab/Fc-mediated binding are also crucial for considering antibody drug response. In this presentation, I would like to share our process for evaluating toxicity in drug discovery and present case studies in which target-mediated toxicities were observed in cynomolgus monkeys.