Host: The Japanese Society of Toxicology
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are linked with age-related intracellular Zn2+ dysregulation induced by rapid influx of extracellular Zn2+. Zn-amyloid β1-42 (Zn-Aβ1-42) complexes formed in the extracellular fluid are synaptic activity-independently taken up into neurons, followed by rapid intracellular Zn2+ dysregulation. In PD, on the other hand, a unique mechanism of nigral dopaminergic degeneration, in which rapid intracellular Zn2+ dysregulation mediated with hydrogen peroxide causes PD in rats, which is induced by paraquart and 6-hydroxydopamine. I will talk about novel defense strategy against neurodegeneration via intracellular Zn2+ dysregulation.
