Host: The Japanese Society of Toxicology
The new coronavirus mutates about 24 out of the 30,000 base sequences in one year. It is a relatively stable RNA virus. Viruses with new mutations are selected about every three months, and the number of infected people rises, then decrease due to self-destruction may happen, drawing a wave.
As a mechanism to create this periodicity, selections are mediated by multi-scale of interactions such as molecular level, host immunity, social isolation and treatment, and zoonotic infections with animals. The pandemic is expected to end in the next few years.
The problem is that with each wave, the number of carriers of a virus called basic clade, which has a relatively stable origin, increases at the epicenter, and mutant strains are produced from there. Of particular concern is the increase in vaccine-resistant viruses that reduce susceptibility and causes prolonged pandemic.
I would like to consider a countermeasure to end the coronavirus pandemic from the view point of the mechanism generating periodicity.
