Chronotoxicity of 6-mercaptoprine in mice

Abstract

The chronotoxicity of 6-MP was investigated using mice. When mice were received single intraperitoneal administration of 6-MP at different administration timings, we obtained the results showing that the severity of toxicity of 6-MP was strong from evening to night (body weight change and lethality were used as indicators). Since the dosage form of 6-MP is only a powdered form in Japan, the occupational exposure of 6-MP to healthcare workers, including pharmacists, has become a problem. Our present data can be a basic finding to prevent health care workers from 6-MP health problems.