Host: The Japanese Society of Toxicology
It is known that various endocrine disrupting chemicals, including vinclozolin and glyphosate induce epigenetic transgenerational inheritance (ETI) in rats. ETI is the germline-mediated epigenetic transmission of information between generations in the absence of direct environmental influences that lead to phenotypic variations.
ETI has been shown to be induced by various environmental factors, including various nutritional conditions and even the nursing status off their mother. In ETI experiment by chemical substances, chemicals were administered at the stage of PGC sof developmental embryos in mice and rats.The importance of PGCs on ETI will be discussed.
