Asbestos exposure-caused altered gene expression in cytotoxic T lymphocyte cell line and difference in those between chrysotile and crocidolite exposure explored by transcriptome analysis

Abstract

The present study examined alteration in gene expression of EBT-8 human CD8+ T cell line exposed to chrysotile A (CA), chrysotile JAWE and crocidolite (CR) over a month by transcriptome analysis. The analysis compared 29,638 transcripts, showing that 4 times or more alterations in expression were found in five, including IFN-γ, while 78 transcripts showed double amount. In contrast, the part of transcripts in CR-exposed cell line showed negative correlation in expression with CA-exposed that. Those obtained results suggest the common genes and the difference in those between chrysotile and crocidolite exposure.