Host: The Japanese Society of Toxicology
Cadmium (Cd) reduced GLUT4 (glucose transporter 4 coded by SLC2A4) in HK-2 cells. Cd treatment and SLC2A4 knockdown caused a significant decrease in intracellular glucose levels. Cd significantly decreased the uptake of glucose into the cells. The decrease in intracellular ATP level was observed by Cd treatment and SLC2A4 knockdown. Long-term exposure to Cd decreased gene expression of Slc2a4 in the kidney of mice. These results indicated that Cd renal toxicity is engaged by the decrease in glucose and ATP level by the suppression of cellular GLUT4 level.
