Cadmium induced ER stress/autophagy response and salubrinal reduced the cell death effect in human neuroblastoma SH-SY5Y cells

Abstract

Salubrinal sustained phosphorylation of eIF2α and regulate cell death, but the mechanism is not clear. In this study, salubrinal significantly prevented the CdCl₂ induced cell death. ER stress/autophagy were responsed by CdCl₂, and further elevated by co-treatment with salubrinal. The mechanism is that salubrinal sustained phosphorylation of eIF2α, resulting in a simultaneous response to ER stress and autophagy, but the CdCl₂ induced CHOP mRNAs were suppressed by salubrinal, which may have prevented cell death. These results recently reported the cooperation of ER stress response and autophagy.