Investigations of the mechanisms of acetamide-induced hepatocarcinogenesis based on the rat strain differences of carcinogenicity

Abstract

Our previous study revealed that acetamide (AA) induced chromosome aberrations (CAs) specifically in rat liver. However, involvement of CAs in its hepatocarcinogenicity remains unclear. In this study, we focused on the difference in tumor incidences between F344 and Wistar rats in carcinogenicity studies and examined inducibility of micronucleus and preneoplastic lesion of the liver in these strains after AA administration. As a result, the number of micronucleated hepatocytes was positively correlated with preneoplastic lesion, suggesting that CAs contributed to AA carcinogenesis.