Relationship between urinary bladder carcinogenicity and urinary metabolites of occupational urinary bladder cancer-related aromatic amines

Abstract

Male rats were treated with aniline (AL), p-toluidine (PT), acetoaceto-o-toluidide (AAOT) or o-toluidine (OTD) for 4 weeks. Simple hyperplasia and increased cell proliferation were observed in urinary bladder of rats treated with AAOT and OTD, but not in rats treated with AL or PT. A larger amount of OTD were detected in the urine of rats treated with AAOT and OTD. In contrast, OTD was no or less detected in urine of rats treated with AL and PT. There results suggested that urinary OTD is a useful metabolite marker for predicting bladder carcinogenicity of aromatic amines in rats.