Host: The Japanese Society of Toxicology
Glycation products cause various inflammatory disorders and accelerate aging. In this study, we have focused on dihydropyrazines (DHPs)—a group of glycation products—and characterized their cellular effects. Recently, we reported that 3-hydro-2,2,5,6-tetramethylpyrazine (DHP-3) suppressed the TLR4-mediated inflammatory signaling pathway in lipopolysaccharide-stimulated HepG2 cells and showed toxicity in a dose-dependent manner. In the present study, to elucidate the molecular mechanism underlying the effects of DHP-3, we examined the role of the receptor for advanced glycation end products.
