Annual Meeting of the Japanese Society of Toxicology
The 48th Annual Meeting of the Japanese Society of Toxicology
Session ID : P-143
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Host: The Japanese Society of Toxicology

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Plasma phosphatidylcholine as a potential biomarker for phospholipidosis induced by amitriptyline
*Kosuke FUKUDA, Kenichi WATANABE, Toichiro YAMADA, Sayo TAKAYAMA, Jun TADANO, Izuru MIYAWAKI
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Abstract

Hepatic phospholipidosis (PL) is one of storage disorders in the liver. Biomarkers (BMs) that reflect progression of PL are very limited. To search for BM candidates for PL, male SD rats was dosed with 150 mg/kg/day amitriptyline for 14 days. Phospholipids in liver and plasma were measured by mass spectrometry. In the results, phosphatidylcholine (PC) (36: 1), PC (36: 4) and PC (38: 5) were increased in liver, and decreased in plasma conversely. It was considered that the decreased phospholipids in peripheral blood might be related to the accumulation of phospholipids in the liver.

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